The smash happened on Broadway, at the junction with the end of Fold Green, right outside the San Rocco restaurant.
The collision occured shortly before 5.30pm, so traffic chaos ensued as many drivers remained stuck on Broadway for around an hour before police eventually allowed cars in the immediate vicinity to move on.
Broadway was blocked off for a spell between Hunt Lane and Thatch Leach, meaning side-roads in the area were extremely busy in the rush hour.
A brief statement from the North West Ambulance Service read: "We attended the scene following a 999 call at 17.25, reporting an RTC.
"Two patients were taken to hospital, including a man in his 30s."
