Linney Lane was closed until 11am following a fire at a disused industrial unit in the early hours of the morning.
It's understood there were three separate blazes which were attended by four fire engines and police.
Linney Lane has now been opened to traffic in both directions, though the public footpatch remains closed to pedestrians.
Police and one fire engine remains at the scene.
A spokesperson for Greater Manchester Fire and Rescue Service (GMFRS) said: “At around 4:15am this morning (Thursday 21 April) we were called to reports of a fire at a derelict industrial building on Linney Lane, Shaw.
“Four fire engines from Oldham, Chadderton, and Rochdale fire stations were quickly in attendance, supported by an aerial platform from Manchester Central. Firefighters wearing breathing apparatus worked hard to tackle the blaze in the two-storey building, extinguishing the flames in sectors using three hose reels and a jet.
“Crews remain in attendance at this time.”
The premises were the home to Shuttleworth Hospital Products, who have since relocated to Ipswich.
