The closures will be in place on August 8, 9, 10 and 11, from 9pm until 6am.
To minimise disruption, the closures will be during the school holidays and also during off-peak hours.
Oldham Way will be closed in both directions between the Kings Road Bridge up to the junction of Prince Street/Oldham Way.
Signposted diversions will be in place.
Essential highways improvements are being carried out as part of Oldham Council's ambitious Southlink regeneration development.
Under the plans, in the region of 150 residential properties would be built, including a mix of mews, semi-detached, housing blocks and flats.
A council statement read: "We’re working hard to improve our transport network – we’re sorry for any inconvenience caused by the works."
