Police were called just before 3:00am to Flora Street in Coldhurst this morning (25 March) to reports a man had been stabbed.
Emergency services attended, a man in his 20s was taken to Royal Oldham Hospital, where he was later pronounced dead.
Six people have been arrested on suspicion of murder, and remain in custody for questioning.
DCI Ben Cottam of GMP's Major Incidents Team said: "Our thoughts are very much with the man's family at this time."
"While this is believed to be an isolated incident, with no wider threat to the public, our team of detectives are working tirelessly to establish the exact circumstances of his death, and to find out who is responsible.
"I would like to be clear that our investigation remains very much ongoing and I would ask anyone with information to come forward. No matter how minor you may think it is, it could prove invaluable to our investigation."
Officers remain on site at Claymoor Court on Flora Street.
