At around 11pm last night (Sunday), officers were called to a report of a collision involving a white Mercedes A200 AMG and a white Toyota Prius taxi at the crossroads on Oldham Road, near the junction with Newmarket Street and Wilshaw Lane in Ashton.
Emergency services attended and a passenger in the taxi, a man in his 20s, was taken to hospital with life-threatening injuries.
The driver, a man in his 30s, suffered minor injuries.
Three people in the Mercedes fled on foot.
An investigation is underway.
Detective Sergeant Marie Eldred, from GMP's Serious Collision Investigation Unit, said: "This was a serious collision that has left a man fighting for his life in hospital.
"We asking anyone with any information or may have seen anything to contact us."
Anyone with information or anyone with dash-cam footage can call 0161 856 4741 quoting log 2942 of 13/12/2020.
Alternatively, contact Crimestoppers anonymously on 0800 555 111.
